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ea0092op-13-02 | Oral Session 13: Pathophysiological actions of thyroid hormones | ETA2023

Induced types 2 and 3 deiodinase in the muscle of critically ill patients correlates with endoplasmic reticulum and mitochondria alterations: Implications to nonthyroidal illness syndrome pathophysiology

Wajner Simone , Braun Andre , Marschner Rafael , Oliveira Thaliane , Argenti Gustavo , Vidart Josi

Dysregulation of types 2 and 3 deiodinases (D2 and D3) alters the metabolism of thyroid hormones in the patients with nonthyroidal illness syndrome (NTIS). Previous studies have demonstrated that deiodinase expression varies in the muscle in different disease models. Nevertheless, the location of D2 and D3 and the effect of oxidative stress on reticulum endoplasmic (ER) and mitochondrial function are not described in human muscle with different types of acute disease and NTIS....

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Induced types 2 and 3 deiodinase in the muscle of critically ill patients correlates with endoplasmic reticulum and mitochondria alterations: Implications to nonthyroidal illness syndrome pathophysiology

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